Please refer to the Section on: Products Available in South Africa
Please Note: Patients with Inhibitors require Special Treatment
Dose depends on bleeding severity
- Minor bleed: 20 – 40 IU/kg
- Major bleed: 40 – 50 IU/kg
Expected response
- 1 IU/kg = 2% rise in Factor VIII level
Half life Factor VIII
- 8-12 hr
For serious bleeding Factor VIII assay may be required to monitor the response to the infusion.
If there is no response to appropriate replacement therapy, test for inhibitors.
Please note:
Please note:
Dose depends on bleeding severity
- Minor bleed: 20 – 40 IU/kg
- Major bleed: 60 – 80 IU/kg
Expected response
- 1 IU/kg = 1% rise in Factor IX level
Half life Factor IX
- 16-24 hr
For serious bleeding Factor IX assay may be required to monitor the response to the infusion.
If there is no response to appropriate replacement therapy, test for inhibitors.
Rehabilitation after a bleed is essential to maintain strength and range of motion.
When to start rehabilitation exercises?
- As soon as the pain is gone.
What exercises?
- Static exercise.
- 3 days after resolution of the bleed: free active exercises where the only resistance is gravity.
- 10 days after the resolution of the bleed: weight bearing exercises to build up muscle strength and bulk.
Any person with Haemophilia and related bleeding disorders may have transfusion acquired infection.
- Test annually for HAV, HBV, HCV.
- Antibody/antigen negative patients should be immunised, and response assessed.
- Active infection should be excluded in positive patients.
- Patients with chronic active hepatitis should be referred to a Hepatologist for management.
